The Philippine Heart Center is seated on a 2.7 hectare lot at the corner of East Avenue and Matalino Street in the Diliman District of Quezon City. It is bounded by the East Avenue Medical Center on its side. Other landmarks within the vicinity are: Bangko Sentral ng Pilipinas (Printing and Mint Plant), National Kidney and Transplant Institute, Social Security System, Quezon City Hall, Sulo Hotel, among others. It has four (4) buildings composed of a five-storey Hospital building, a nine-storey Medical Arts building with a two-storey Annex, and the two-storey Nuclear Medicine building. Also, government offices like the Development Bank of the Philippines (1st floor) and Tariff Commission (5th floor) have their offices here.

The PHC hospital proper is a 354-bed tertiary care center. There are twenty-one nursing units, including 53 Intensive Care Unit (ICU) beds, 24 suites, 56 private rooms, a presidential suite, 74 semi-private rooms, 3 adult service wards, and a pediatric service ward. Its design of having 4 petals in each floor represents the 4 chambers of the human heart.